Sun Y, Lai MS, Lu CJ. They can support nerve repair in neuropathy. Eur J Pain. An inadequate diet is one of the most common causes of an underactive thyroid. 54 Likes, 13 Comments - Residents (@lapmrresidency) on Instagram: “Resident’s Corner: Name: David Huy Blumeyer, MD Year in residency: PGY-4 Where were you born…” J Clin Neuromuscul Dis. Acta Neurol Taiwan. This could influence the use/ effectiveness of dietary supplements, herbs and alternative treatments for the same. Vitamin B helps strengthen antioxidant defences and protects the nerve from oxidative damage and neuropathy. Proc West Pharmacol Soc. Exp Clin Endocrinol Diabetes. (Neurological Clinics, 2013). All Rights reserved. Vitamin B12 deficiency: HYPOTHYROIDISM -Binod timalsina 2. 2004;47:88-91. ALL YOUR PAPER NEEDS COVERED 24/7. are few of the risk factors for vitamin B deficiency. A few studies have found B vitamins to be ineffective in peripheral neuropathy treatment. Clinicopathologic features of folate-deficiency neuropathy. Quick Gist: The most common vitamin B deficiencies observed in peripheral neuropathy are folate, vitamin B12 and vitamin B1 deficiencies. Jaeger B, Bosch AM. • Pregabalin group: Starting with 75mg/day to 600mg/day. Biemans E, Hart HE, Rutten GE, Cuellar renteria VG, Kooijman-buiting AM, Beulens JW. The study looked at data on more than 4,000 patients hospitalized with COVID-19. Vol 8 (1). I am suffering from calpol tunnel syndrome. 2014;18(1):76-85. It contains methylated proteins. C. F. Verschraegen, M. Royce, S. J. Lee, S. Movva, L. Susan, and G. Michael. 2013;65(9):1077-82. This is one of the largest online sources of natural health information available. Copyright © 2011-2020. A study in 48 patients with peripheral entrapment neuropathy demonstrated that a combination of uridine monophosphate, folic acid and vitamin B12 (Keltican®) for 2 months is found to decrease nerve pain and lower the use of painkillers. Oxidative stress plays a major role in nerve damage and progression of peripheral neuropathy. Solomon LR. Please read our Terms and Conditions and Privacy Policy. 1999;49(3):220-4. Several nutrient deficiencies worsen neuropathy such as magnesium deficiency, vitamin E deficiency and vitamin B deficiency. The vitamin B group showed a 30% reduction in symptoms which was comparable to the effect of 900mg/day of pregabalin. Vitamin B complex help in neuropathy by reducing pain and supporting nerve repair. Vitamin B12-responsive neuropathies: A case series. The Counseling Sheets CD is available for $50.00 by calling 1-877-UCHEEPINES or 1-334-855-4764. (02/16/2021) Anticoagulation medication could lower the risk of death from COVID-19, according to a study by VA researcher and colleagues. Nutr Neurosci. 2009;47(2):184-8. The dosage of Shilajit varies according to patient’s age, body weight, diseases, and health conditions. 2014;16(1):25-31. Negrão L, Nunes P. Uridine monophosphate, folic acid and vitamin B12 in patients with symptomatic peripheral entrapment neuropathies. Nutritional neuropathies. Early or continuous supplementation with vitamin B can reduce the risk of developing neuropathy with levodopa treatment. Folate can be obtained from dark leafy greens, fruits, poultry, dairy products, and meats. Tingling in the hands and feet is often associated with other symptoms like pain, burning, or numbness in the hands and feet.These type of sensations commonly reflect damage to the nerves in the area (neuropathy); because these are peripheral areas of the body, the term peripheral neuropathy is used to refer to this type of symptom. When a person experiences paresthesia, symptoms from a wide-range of possibilities may occur. However, some studies do suggest that it may not improve the electric activity of the nerve. Allodynia refers to pain response to a stimulus that would not cause pain in normal conditions. Hypothyroidism 1. 2016;38(8):717-24. Clinical results of a cross-over treatment with pyridoxine and placebo of the carpal tunnel syndrome. This site uses Akismet to reduce spam. There is a generalized slowing down of metabolic processes. Drug Saf. 2016;7(5):777-85. Caram-salas NL, Medina-santillán R, Reyes-garcía G, Granados-soto V. Antinociceptive synergy between dexamethasone and the B vitamin complex in a neuropathic pain model in the rat. Yu CZ, Liu YP, Liu S, Yan M, Hu SJ, Song XJ. Uchee Pines is committed to assisting people through the use of simple, natural methods, using exercise, vegetarian nutrition, hydrotherapy, massage, the rational and judicious use of some herbs and supplements, and firm faith in the Divine Healer. [How much vitamin B6 is toxic?]. Schloss JM, Colosimo M, Airey C, Vitetta L. Chemotherapy-induced peripheral neuropathy (CIPN) and vitamin B12 deficiency. Yu and colleagues have observed that B vitamins reduce nerve pain by protecting the function of neurotransmitter GABA. Treatment with vitamin B complex and Benfotiamine (Allithiamine, a garlic-derived fat-soluble form of vitamin B1) for nine months was found to improve nerve function parameters such as vibration perception and nerve conduction velocity in diabetic neuropathy. The author cannot assume the medical or legal responsibility of having this information misinterpreted and considered as a prescription for any condition or any person. It can be taken in combination with vitamin B complex or alone. • Producing energy in the cells South Med J. This is one of the largest online sources of natural health information available. Neurology. Symptomatic treatment of painful diseases of the peripheral nervous system with a combination preparation of thiamine, pyridoxine and cyanocobalamin]. 2016;6(1):25-9. 1992;110(29):544-8. Sechi G, Sechi E, Fois C, Kumar N. Advances in clinical determinants and neurological manifestations of B vitamin deficiency in adults. Complex B vitamins: Physiology and Therapeutic Effect on Pain. Seale, Alabama 36875, Phone (U.S. only): 1-877-UCHEEPINES (1-877-824-3374) Treatment with a multi-vitamin, vitamin B6 and B12 reduced nerve pain caused by cold temperatures and improved nerve health and physical well being in patients receiving taxane chemotherapy. This was 3+ … A study published in the Journal of Diabetes Research, 2016 demonstrated that combination of vitamin B and gabapentin (a medicine prescribed for nerve pain) was as effective as pregabalin (nerve pain medication) alone in treating painful diabetic neuropathy. Ned Tijdschr Geneeskd. Peripheral neuropathy has a … For example, chronic kidney failure patients with peripheral polyneuropathy are found to respond to vitamin B6 therapy rather than vitamin B12 supplementation even if no vitamin B6 deficiency was observed. The symptoms included numbness, impaired balance, unsteady gait and slipping of footwear while walking. Kaishore guggulu tablets: 2 to 4 tablets twice a day. Though neuropathy treatment would require vitamin B supplementation, it is great to include certain vitamin B rich foods in the diet. Neuromuscul Disord. A study published in the Journal of Diabetes Research, 2016, Journal of Inherited Metabolic Disease, 2016, cause a vitamin B5 (pyridoxine) deficiency, deficiency could cause painful nerve damage and neuropathy, Levodopa treated Parkinson’s patients may experience neuropathy, chemotherapy-induced peripheral neuropathy, A case report published in the International Journal of Basic and Clinical Pharmacology, 2019, severe vitamin B deficiency is observed in alcohol use disorder, American Journal of Pharmacological Sciences, 2016, Activation of GABA receptors is found to reduce neuropathic pain, Addition of vitamin B12 to painkiller diclofenac increases its anti-allodynic effect, most commonly prescribed drugs for treating neuropathy, The Cochrane Database of Systemic Reviews, 2008, Alpha Lipoic Acid in reducing neuropathy symptoms, A study published in Nutritional Neuroscience, 2014, Certain neuropathies may respond to vitamin B12 therapy, This deficiency can cause depression, neuropathy and cognitive decline in diabetes patients, Benfotiamine (fat-soluble vitamin B1) is effective in reducing neuropathic pain, Experimental and Clinical Endocrinology & Diabetes, 1996, A study published in the International Journal Of Food Sciences and Nutrition, 2009, Acetyl-L-carnitine, an amino acid, helps in neuropathy, Nephrology, Dialysis and Transplantation, 2000, A review study published in the Singapore Medical Journal, 2016, Magnesium which also benefits in neuropathy and nerve pain, https://www.ncbi.nlm.nih.gov/pubmed/8909981, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199287/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920840/, https://www.ncbi.nlm.nih.gov/pubmed/27034475, https://www.ncbi.nlm.nih.gov/pubmed/11506323, https://www.ncbi.nlm.nih.gov/pubmed/25137514, https://www.ncbi.nlm.nih.gov/pubmed/25663227, https://www.ncbi.nlm.nih.gov/pubmed/10889340, https://www.ncbi.nlm.nih.gov/pubmed/2164084, https://www.ncbi.nlm.nih.gov/pubmed/23989342, https://www.ncbi.nlm.nih.gov/pubmed/28608472, https://www.ncbi.nlm.nih.gov/pubmed/2537891, https://www.ncbi.nlm.nih.gov/pubmed/25863665, https://www.ijbcp.com/index.php/ijbcp/article/view/3001, https://www.ncbi.nlm.nih.gov/pubmed/28213665, https://www.ncbi.nlm.nih.gov/pubmed/22940269, https://www.ncbi.nlm.nih.gov/pubmed/11981157, https://www.ncbi.nlm.nih.gov/pubmed/24038589, https://www.ncbi.nlm.nih.gov/pubmed/15633622, https://www.ncbi.nlm.nih.gov/pubmed/15633621, https://www.ncbi.nlm.nih.gov/pubmed/1330858, https://www.ncbi.nlm.nih.gov/pubmed/26679082, https://www.ncbi.nlm.nih.gov/pubmed/15633618, https://www.ncbi.nlm.nih.gov/pubmed/27334563, https://www.ncbi.nlm.nih.gov/pubmed/15633627, https://www.ncbi.nlm.nih.gov/pubmed/26885528, https://www.ncbi.nlm.nih.gov/pubmed/18646107, https://www.ncbi.nlm.nih.gov/pubmed/19409980, https://www.ncbi.nlm.nih.gov/pubmed/24018744, https://www.ncbi.nlm.nih.gov/pubmed/24256995, https://www.ncbi.nlm.nih.gov/pubmed/24835269, https://www.ncbi.nlm.nih.gov/pubmed/25710280, https://www.ncbi.nlm.nih.gov/pubmed/20134380, https://www.ncbi.nlm.nih.gov/pubmed/25315630, https://www.ncbi.nlm.nih.gov/pubmed/16008162, https://www.ncbi.nlm.nih.gov/pubmed/8886748/, https://www.ncbi.nlm.nih.gov/pubmed/19212856, https://www.ncbi.nlm.nih.gov/pubmed/27180954, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920214/, https://www.ncbi.nlm.nih.gov/pubmed/28983799, https://ascopubs.org/doi/abs/10.1200/jco.2009.27.15s.e20621, https://www.ncbi.nlm.nih.gov/pubmed/10978399, https://www.ncbi.nlm.nih.gov/pubmed/26892473, https://www.myfooddata.com/articles/thiamin-b1-foods.php, http://www.whfoods.com/genpage.php?tname=nutrient&dbid=100, https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/, https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/, https://www.ncbi.nlm.nih.gov/pubmed/29737502, https://www.ncbi.nlm.nih.gov/pubmed/16320662, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848223/, https://www.ncbi.nlm.nih.gov/pubmed/10219465, https://www.ncbi.nlm.nih.gov/pubmed/18060778, Spirulina For Parkinson’s: Research & Safety, Holy Basil (Tulsi) For Alcoholism: Research, Potential Benefits & Safety, Nigella Sativa (Black Cumin Oil) For Memory: Research & Safety, Krill Oil For Memory: Research, Benefits & Safety, Essential Oils For Chronic Fatigue Syndrome: Research, Benefits & Safety, Quercetin For Chronic Fatigue Syndrome: Research & Possible Benefits, Massage For Chronic Fatigue Syndrome: Research & Benefits. • Metabolism of amino acids J Diabetes Res. 2004;47:92-4. This deficiency may cause reduced nerve fibre density contributing to neuropathy. They also improved nerve function parameters. I removed blood clots in my swelling kidney. Your email address will not be published. 2005;149(46):2545-6. Vitamin B12 deficiency can cause neuropathy in some cases. Proc West Pharmacol Soc. (Brain Nerve, 2013). DNA methylation is an important process which involves the addition of methyl group to DNA sequences and regulates the expression of genes. Birch CS, Brasch NE, Mccaddon A, Williams JH. A study published in Nutritional Neuroscience, 2014 revealed that 3-6 month therapy with cyanocobalamin improved nerve conduction, reduced neuropathy and supported clinical recovery in patients with vitamin B12 deficiency neurological syndrome. Uchee Pines Institute, through the contributions of Dr. Agatha Thrash and others, has collected scientific health and natural remedies information on hundreds of health topics. 1996;27(6):995-1000. Vitamin B12 deficiency is commonly observed in patients with diabetes who use metformin (an anti-diabetes medication). Correcting vitamin B deficiency is found to reduce the risk of neuropathy symptoms in conditions like Parkinson’s disease, bariatric surgery and chemotherapy-induced peripheral neuropathy. Nutritional neuropathies, as the name suggests, arise from nutrient deficiencies. Supplementing with vitamin B12 can help reduce the risk of and prevent progression of diabetic neuropathy. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the side effects associated with certain chemotherapeutic agents such as platinum agents, taxanes, vinca alkaloids, thalidomide, and bortezomib. 2012;91(23-24):1187-95. This could be attributed to the dosage or the supplementation of particular members of the B complex group. Vitamin B12 may interact with medications like chloramphenicol, proton pump inhibitors, histamine antagonists, metformin, etc. They are allergen free and vegetarian capsules. Okada H, Moriwaki K, Kanno Y, et al. Eckert M, Schejbal P. [Therapy of neuropathies with a vitamin B combination. Alvarado, A. M. , & Navarro, S. A. A mini-review published in Current Oncology Reports, 2017 revealed that vitamin B complex can help in the prevention of chemotherapy-induced peripheral neuropathy. Last Updated on April 7, 2019. Dosage. Mimenza alvarado A, Aguilar navarro S. Clinical Trial Assessing the Efficacy of Gabapentin Plus B Complex (B1/B12) versus Pregabalin for Treating Painful Diabetic Neuropathy. Please consult your health practitioner before taking any supplements for the same. The combination of thiamine (vitamin B1) and pregabalin are found to have an additive pain-relieving effect and can benefit in the treatment of neuropathic pain and neuropathy. This could be explained by the fact that severe cases may require vitamin B injections and some may require supplementation with a particular vitamin from the B complex group. Quick Gist: Supplementation with a combination of B vitamins can help reduce neuropathic pain significantly within 2-3 months. Pain Manag. Dosage of Doxycycline for Sinus Infection. It can be found in certain foods such as milk, meat, eggs, nuts, enriched flour, and green vegetables. Folate and vitamin B12 deficiency may contribute to alcoholic neuropathy. 2004;47:76-9. View abstract. (Neurological Clinics, 2014). Neurosci Lett. Vitamin B6 is mostly found in organ meats, fish, poultry and starchy vegetables. preliminary results. Talaei A, Siavash M, Majidi H, Chehrei A. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. B complex vitamins are essential for maintaining good nerve health. Intramuscular injections may be necessary in some cases. Curr Oncol Rep. 2017;19(12):76. 2000;15(9):1410-3. 2016;2016:4078695. 2010;103(3):265-7. Kaishore guggulu powder: 500 mg to 1 gram twice a day. Activation of GABA receptors is found to reduce neuropathic pain. • Gabapentin + vitamin B group: Starting with 300mg gabapentin to 3600mg at the last visit and 100mg vitamin B1 and 0.20mg vitamin B12. Rajabally YA, Martey J. Levodopa, vitamins, ageing and the neuropathy of Parkinson’s disease. They lower antioxidant defences and cause oxidative damage to nerve cells in neuropathy. Anesthesiology. While this trend was observed at high dose and long term use, even low doses such as less than 50mg/day were associated with neuropathy. (Please: Do not contact Phylis with health or literature questions!). 234 patients with diabetic neuropathy received 500mg ALCAR thrice a day or 0.5mg methylcobalamin thrice a day for 24 weeks. There are various strengths of Doxycycline for sinus infection- 50, 75, 100, and 150 mg. Research in animal models confirms that vitamin B and dexamethasone act synergistically to reduce nerve pain. A case report published in the International Journal of Basic and Clinical Pharmacology, 2019 described symptoms of neuropathy in a patient being treated with carbamazepine for seizures. Gamma-aminobutyric acid or GABA is a neurotransmitter or chemical in the brain that is said to have a calming effect. www.salubrainous.com participates in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. Quick Gist: Supplementation with vitamin B6 and B12 may reduce the risk of chemotherapy-induced peripheral neuropathy. Granados-soto V, Sánchez-ramirez G, La torre MR, Caram-salas NL, Medina-santillán R, Reyes-garcía G. Effect of diclofenac on the antiallodynic activity of vitamin B12 in a neuropathic pain model in the rat. One can test for vitamin B deficiency to identify which vitamin supplement could benefit. Malan TP, Mata HP, Porreca F. Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Verschraegen and colleagues have shown that vitamin B6 and B12 can reduce chemotherapy-induced neuropathy in taxane-based chemotherapy. Van hunsel F, Van de koppel S, Van puijenbroek E, Kant A. Vitamin B in Health Supplements and Neuropathy: Case Series Assessment of Spontaneously Reported Cases. A tumor or vascular lesion pressed up against the brain or spinal cord can also cause paresthesia. Vitamins B6 and B12 supplementation to prevent chemotherapy-induced neuropathy (CiN): Interim analysis of the taxane cohort. Preclinical research shows that chemotherapeutic agents cause nerve degeneration, impair nerve structure and causes mitochondrial dysfunction in nerve cells leading to CIPN. Am J Clin Nutr 1979;32:2040-6. However, vitamin B6 at high doses or in excess can cause toxicity and even sensorimotor neuropathy. Winkler G, Pál B, Nagybéganyi E, Ory I, Porochnavec M, Kempler P. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. The dose of vitamin B complex for peripheral neuropathy treatment is dependent on the severity and nature of the condition. Researchers also noted that pregabalin alone could help achieve pain reduction at 50% of the minimum dose of gabapentin. 1996;104(4):311-6. Read about diseases and conditions that may cause hand and finger numbness (paresthesia) and the medications used in treatment. Ang CD, Alviar MJ, Dans AL, et al. Ilathamizhan Jayakumar, Jayanthi Mathaiyan. Certain medications can cause vitamin B deficiencies and contribute to neuropathy symptoms and nerve pain. Skelton WP, Skelton NK. (The Journal of Diabetes Research, 2016) Addition of vitamin B1 and B12 to gabapentin was found to be as effective as pregabalin alone in reducing nerve pain. Adjuvants. Also, the addition of vitamin B reduced the dosage of gabapentin required for pain relief. Research suggests that supplementation with B vitamins can help reduce the risk of chemotherapy-induced peripheral neuropathy. Quick Gist: Vitamins from the B complex family are involved in various aspects of nerve health such as nerve conduction, development of myelin sheath and other structural aspects. 2016;19(4):162-8. It can be obtained from milk, eggs and meat products. Vitamin B deficiency is observed in peripheral neuropathy. Addington J, Freimer M. Chemotherapy-induced peripheral neuropathy: an update on the current understanding. (Neurological Research, 2016). Thiamine or vitamin B1 can be obtained from whole grain foods, poultry, lean meats, seafood, nuts, soy foods, etc. Acta Neurol Scand. The dosage of vitamin B1 for neuropathy is 100 mg per day. In some cases, it can even reverse neuropathy. Negrão L, Almeida P, Alcino S, et al. Katan MB. Even in humans, vitamin B supplementation has proven to reduce neuropathic pain with 2-3 months of therapy effectively. 2008;(3):CD004573. B complex vitamins can increase the pain-relieving effect of steroids and analgesics if taken together. Home » Neurological Diseases » Neuropathy » Vitamin B Complex For Neuropathy, How it works | Research | Food Sources | Dosage and Uses | Precautions | Suggested Products | Conclusion. Addition of vitamin B12 to painkiller diclofenac increases its anti-allodynic effect and reduces neuropathic pain in an animal model. Folate (Vitamin B9) deficiency neuropathy differs from thiamine (Vitamin B1) deficiency neuropathy; it is slowly progressing and can affect sensory neurons significantly. Such drug or health condition induced B complex deficiencies can be alleviated with supplementation which may aid in reversing neuropathy. In some cases, neuropathies may respond to vitamin B12 treatment even in the absence of a deficiency. Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin. 69% of the patients treated with vitamin B experienced a reduction in nerve pain within 1 month. (Pain Management, 2014). The dosage of Vitamin B12 for neuropathy ranges from 20 mcg to 1,840 mcg (cyanocobalamin) daily while for methylcobalamin, it is 4 mg and 1,500 mg daily. Life Sci. However, it also noted that high-dose vitamin B could help resolve pain and numbness. 2017;136(6):660-667. Moisturizers and antioxidants allow this powerful cream to easily absorb into the skin. Schloss J, Colosimo M. B Vitamin Complex and Chemotherapy-Induced Peripheral Neuropathy. Free Radic Biol Med. Neuropathic pain or nerve pain in peripheral neuropathy is characterised by burning sensation, pins and needles sensations, stabbing pain and electric shock-like sensations. Vitamin B12 supplementation helps in neuropathy. Nerve entrapment syndromes, such as carpal tunnel syndrome, can damage peripheral nerves and cause paresthesia accompanied by pain. Pinpoint your symptoms and signs with MedicineNet's Symptom Checker. Acetyl-L-carnitine, an amino acid, helps in neuropathy by supporting nerve regeneration. Hypothyroidism Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones. Vitamin B deficiency neuropathy. Liu L, Ma SH, Xia LJ. Riboflavin is a B vitamin. Acetyl-l-carnitine was found to be as effective as vitamin B12 in improving diabetic neuropathy. It contains all B complex vitamins in a bioavailable form with an extra dose of vitamin B12. Your PNS controls body movements, sensations, and automatic functions like blood pressure and sweating. The Cochrane Database of Systemic Reviews, 2008 stated that there is insufficient evidence to comment on vitamin B’s effectiveness in peripheral neuropathy. Certain health conditions, in addition to a poor diet, cause vitamin B deficiency. Acta Diabetol. It is involved in reactions that are vital for myelin sheath (covering on the nerve cells) development, and its deficiency could cause painful nerve damage and neuropathy. Vitamin B12 was more effective than nortriptyline in reducing in pain, pins and needles sensation and tingling sensation. The Cochrane Database of Systemic Reviews, 2008 reported that there is insufficient data to comment on vitamin B’s efficacy in peripheral neuropathy. Sponne IE, Gaire D, Stabler SP, et al. 2016 May;74(5):281-300. 2014;4(3):191-6. Carbamazepine is a drug prescribed for treating epilepsy, seizures and neuropathic pain. B complex vitamins are safe if taken in recommended dosages. A significant reduction in pain and improvement in the quality of life was observed in both groups. Please read the ingredient list before purchasing any supplement. The reason for this is that vitamin B12 is an antioxidant and neurotrophic agent (supports the growth and development of nerve cells. conducted a clinical trial to compare the effects of acetyl-l-carnitine with vitamin B12 in diabetic neuropathy. Benfotiamine (fat-soluble vitamin B1) is effective in reducing neuropathic pain. Both ALCAR and vitamin B12 lowered symptoms of neuropathy and also reduced disability associated with it. It contains benfotiamine or Allithiamine which is a garlic-derived soluble form of vitamin B1. Research in an animal model has shown that a combination of B vitamins (B1 or thiamine, B6 or pyridoxine, B12 or cyanocobalamin) helps relieve neuropathic pain. (The Journal of Nutrition, 1989). 2018;41(9):859-869. B vitamins may protect from toxic effects of certain chemotherapeutic agents by preserving nerve structure and boosting cellular antioxidant defences.
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